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10.1007/s00432-006-0164-y

Cellular ROS and antioxidants: physiological and pathological role

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While toll-like receptors (TLRs) signaling ensures protective immune response by recognizing invading pathogens and tissue-derived endogenous molecules, its overactivation perturbs the immune homeostasis by sustained release of pro-inflammatory mediators and subsequently underlies the development of many inflammatory diseases [296]