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Given that reactive oxygen species (ROS) may trigger inflammation by promoting pro-inflammatory cytokines and activating the NF-B pathway, LCs antioxidant action indirectly reinforces its anti-inflammatory effects

Clarifying the difference of metabolic profiles and of molecular mechanisms between HFrEF and HFpEF might provide clinical significance of carnitine metabolism as new therapeutic target for metabolic disorder in hypertensive HFpEF, remaining unmet medical needs in cardiovascular medicine

Well-designed trials are necessary to examine whether L-carnitine could be helpful in the management of cramps

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Similar patterns of associations were evident using weighted median and weighted mode (Additional file 2: Fig
