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Notably, druglikeness scores were extremely skewed toward the upper range (910), confirming the observation that compounds with activity against both targets are likely to have properties in accord with Lipinskis rule of five and other medicinal chemistry principles

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Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through Inhibition of ERK1/2 and Cyclin D1

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

Measurement of Oxygen consumption rate and Extracellular acidification rate Oxygen consumption rate (OCR) and Extracellular acidification rate (ECAR) were measured using the Seahorse XF Pro Analyzer (Agilent Technologies)

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