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Mice pretreated with the GSH synthesis inhibitor BSO had substantially decreased tissue concentrations of GSH, and oral administration of GSH to these animals resulted in statistically-significant increases in the GSH concentrations of kidney, heart, lung, brain, small intestine and skin but not in liver

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These vesicular systems improve drug solubility, targeting, and retention in the stratum corneum, thereby augmenting therapeutic outcomes

(141) in conjunction with chemotherapeutic drugs can reduce the resistance of tumor tissues