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475 Accordingly, GC-based investigations have been vital for the successful development of the oxylipin field and many of the steps in the metabolic pathway for AA were elucidated using the conventional techniques of thin layer chromatography (TLC) and GC

doi: 10.1007/s12035-020-02023-z 7 HaqueMMNilssonEEHolderLBSkinnerMK

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Mechanistically, dual-pathway signaling is plausible, but strong clinical outcome data in humans are limited

For instance, studies in Oatp1a/1b knockout mice suggested that Oatp1a/1b transporters are involved in hepatic uptake of glucuronidated bilirubin (van de Steeg et al., 2010)