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mRNA therapy for pompe disease (2023)

Mitra Varuna

FASEB J 18:14101412 Ukai M, Takada A, Sasaki Y, Kameyama T (1997) Stimulation of delta1- and delta2-opioid receptors produces amnesia in mice

Used clinically for anti-VEGF drugs proving concept
Shaking introduces significant mechanical stress that can break the delicate chemical bonds holding the peptide chain in its specific, functional shape

Each was characterized historically as a lipotropic agent, and each is proposed to contribute to fat handling in a slightly different way