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As a result, upregulation of NRF2 target genes resulted in growth advantages and cisplatin resistance of lung cancer cells.17 Although the nature of NRF2 mutations, which involve direct DNA changes, results in loss of affinity for binding to the KELCH region, the KEAP1 mutations create steric hindrance and gross structural changes in the formation of the NRF2:KEAP1 complex

Similarly, Lactobacillus plantarum HNU082 enriches Bifidobacterium pseudolongum and increases short-chain fatty acids (SCFAs), which strengthens the epithelial barrier and suppresses NF-B signaling

Published online February 26, 2020 DOI: 11,395 View 223 Download 19 Web of Science 19 Crossref Graphical Abstract Abstract PDFSupplementary MaterialPubReader ePub Background Notch signaling pathway plays an important role in regulating pancreatic endocrine and exocrine cell fate during pancreas development