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Studies suggest its fat-metabolism effects are not directly mediated via 3-adrenergic receptors, though it may increase 3-receptor expression, potentially improving lipolytic sensitivity over time

Axonal degeneration Animal and human studies have demonstrated that the long-term use of the platinum derivatives [62, 63] paclitaxel [64], vincristine [65], and bortezomib [66] can induce axonal degeneration, specifically, the loss of large myelinated, small unmyelinated and intra-epidermal nerve fibers

Used alone or in addition to other medications for the treatment of schizophrenia
