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Furthermore, MitoQ has been evaluated in several clinical trials and has shown overall good tolerability, with nausea and vomiting being the most commonly reported side effects (79)

Authors' Contributions Liu JR, Deng ZH, Zhu XJ, Zeng YR, Guan XX, and Li JH contributed to this paper

However, our hypothesis is also consistent with the fact that for the first time we show that while vitamin B 12 deficiency was closely associated with metformin dose, consistent with previous studies [1, 8], it was not associated with plasma concentrations of metformin (Fig

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