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As previously described, a small no-stress condition ( N = 4 females, 3 males) was also included 22

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In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [seeDOSAGE AND ADMINISTRATION,and WARNINGS]

[DOI] [PMC free article] [PubMed] [Google Scholar] [46].Arai M, Imai H, Sumi D, et al