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Science 343 , 183186 (2014)
Role of GABA in anxiety and depression
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However, in oxidative stress or metabolic alteration the electrophiles- and ROS-induced oxidation and modification of KEAP1 sensor cysteines lead to inhibition of KEAP1-mediated Nrf2 degradation and thereby Nrf2 accumulates in the nucleus and activates cytoprotective and metabolic genes [167,168]
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