glutamine glutathione metabolism drives synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines Frontiers | Glutamine's double-edged sword:

2) Therapeutic limitations and innovations: Current ferroptosis inhibitors (Fer-1, Lip-1, and DFO) suffer from poor aqueous solubility, short half-lives, and off-target effects (e.g., DFO-induced iron deficiency anemia)

In the event DSIP does ultimately undergo clinical development, intranasal administration can ensure a higher degree of patient compliance by eliminating side effects and discomfort commonly associated with peptide injections

So Once again, this result makes sense on two levels

Lower cellular dye concentrations due to depolarized mitochondrial membrane potential results in the accumulation of green fluorescent monomeric forms of JC1 (~ 529 nm)

(2013) published in Molecular and Cellular Biochemistry

doi:10.1016/s00916749(97)800085 van den Berg NWE, Neefs J, Berger WR, et al