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NAFLD presents itself as a syndrome characterized by the accumulation of fat along with hepatocellular steatosis, ballooning degeneration, lobar inflammation, and predominantly fibrosis (Tilg and Moschen, 2010), mitochondrial dysfunction ( Chinese herb medicine (CHM), as an integral part of traditional Chinese medicine (TCM), has unique theories and practical experiences in treating chronic diseases (Shi et al., 2020)

In contrast, CHOP, which is itself transcriptionally upregulated by ATF4, acts as a negative feedback regulator

10.1038/s41598-019-48059-7 58 ChenH.GuoY.HuM.DuanW.ChangG.LiC

They improve sleep quality, which is when most tissue repair occurs