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Excessive levels of reactive oxygen species (ROS) could lead to dysfunction of mitochondria by inhibiting the breathing process and resulting in reduced energy expenditure in adipocytes and, on the contrary, improvement of energy accumulation in adipose tissue

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A recent review highlights the importance of determining the APOE -dependent effects of ketogenic dietary modifications, as well as identifying effective doses of dietary compounds to improve clinical outcomes [263]

Altered FoxO1 and PPAR interaction in age-related ER stress-induced hepatic steatosis

Johansson LF, van Dijk F, de Boer EN, van Dijk-Bos KK, Jongbloed JD, van der Hout AH, Westers H, Sinke RJ, Swertz MA, Sijmons RH, Sikkema-Raddatz B

Salomo, E