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LH regulates the testosterone secretion by somatic Leydig cells located in the interstitium, between seminiferous tubules

Therefore their ability to absorb the B12 is also compromised

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Li Q, Li J, Yin L, Huang J, Liu X, Shi J, et al

The current shortage of non-human primates (NHPs), recognized by the regulatory agencies (1), makes it even harder for drug developers to generate the preclinical pharmacokinetic (PK), safety, and efficacy data required to file investigational new drug applications