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Topical application of 1-methylnicotinamide in the treatment of rosacea: a pilot study

In cross-sectional studies, low circulating IGF-I levels were found to be associated with angiographically documented coronary artery disease[275] and may predict fatal ischemic heart disease[272], a significantly increased risk of ischemic stroke and congestive heart failure in elderly patients[276, 277], as well as a worse prognosis of recovery after an acute myocardial infarction[278]

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Gliotransmitter release from astrocytes: functional, developmental, and pathological implications in the brain

Serious: Pulmonary toxicity (e.g., pneumonitis, fibrosis), hypersensitivity reactions, and dermatological effects such as erythema and hyperpigmentation