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This four-base interaction is thought to stabilize the 3 end of the tRNA in the A-site

Deficiency in vitamin B6 is commonly linked to malnutrition, alcoholism, malabsorption syndromes, or as an adverse effect of certain medications, such as cyclosporine, hydralazine, cycloserine, penicillamine, isoniazid, levodopa, phenelzine and chemotherapy treatments (, , , )

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