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Folic acid also plays a critical role in preventing neural tube defects and other birth defects, making testing crucial for pregnant women or those planning pregnancy
Lancet 2007;369:6070
Structural and mutagenesis experiments revealed other important residues in the catalytic site like Glu146, Trp189, Trp125, Ser126, Thr221 and Arg127 [38-40, 59-60]
Srinivasan K, Thomas T, Kapanee AR, et al
