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Conversely, if thyroid dysfunction prompted the visit and pernicious anemia surfaces during workup, the thyroid condition sequences as principal diagnosis

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It can bind to VEGF-A to inhibit the activity of VEGF and block its interaction with VEGFR-1 and VEGFR-2 (82), including endothelial cell enhanced vascular permeability activity, mitogenic activity and other pro-angiogenic activities, to inhibit tumor angiogenesis (81)

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