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Animal models are useful for generating hypotheses and understanding mechanisms, but they do not reliably predict human outcomes

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declares having received consulting honoraria from Amgen, Boehringer Ingelheim, Merck, Pfizer, Aegerion, Novartis, Sanofi, Takeda, Novo Nordisk and Bayer, and research grants from British Heart Foundation, MRC (UK), NIHR, PHE, MSD, Pfizer, Aegerion, Colgate and Roche

showed a similar effect in cell culture, where increased H 2 O 2 production at 18% O 2 versus 5% O 2 could be largely abolished by pharmacological inhibition of NOX activities (Maddalena et al

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