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In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders

To elucidate the precise mechanism of Ag-mediated inhibition in HSC-T6 cells, we evaluated the expression of cell death-associated proteins, including Caspase 3, BCL2, and Bax (markers in apoptosis), Caspase 9 and GSDMD (markers in pyroptosis), and RIP3 (marker in necroptosis)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Carrillo, J

[6] As such, to this day, clomipramine remains the only TCA that is available in the United States that is not approved for the treatment of depression, in spite of the fact that it is a highly effective antidepressant

Therefore, these data support the hypothesis that the metabolic effects associated with the use of thiazide, thiazide-like, loop-diuretics are related, at least in part, to direct or indirect effects on islet -cell secretory function