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In addition to activating the NLRP3 inflammasome cascade (IL-1 and IL-18), damaged mitochondria can t rigger interferons and other pro-inflammatory cytokines

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The rapid shifts in osmolarity associated with HD also increase the risk of further elevations in intracranial pressure, especially in neonates

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however, a retrospective study of 974 healthy women taking spironolactone for acne found only 0.72 percent of serum potassium measurements were abnormal compared to the 0.76 percent baseline rate of hyperkalemia.[49] Considering these results and other similar reports, many dermatologists deem routine potassium monitoring as unnecessary for healthy women on spironolactone, but ultimately, lab monitoring is left to each providers discretion