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Some researchers have shown that metformin activates AMPK and triggers the downstream GSH system to slow DOX-mediated oxidative impairment in the myocardium [225, 226]

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[DOI] [PubMed] [Google Scholar] 147.Neuschwander-Tetri BA, Nicholson C, Wells LD, Tracy TF., Jr Cholestatic liver injury down-regulates hepatic GSH synthesis

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Experimental and Therapeutic Medicine