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These anti-inflammatory and neuroprotective properties are enhanced by vitamin Ds ability to upregulate antioxidant-related genes, including those encoding superoxide dismutase and thioredoxin reductase ( While the -lactam component was intended to increase EAAT2 expression and reduce glutamate toxicity (Takahashi et al., 2015), EAAT2 levels were surprisingly lower (17.51% of control) in the PPA-combination group