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10.1016/j.spen.2020.100829 59 FryeR

In normal physiologic state, the brain parenchyma is only subject to nascent immune surveillance, however during inflammation, the elevated pro-inflammatory markers induce the increased expression of adhesion molecules like intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the endothelial cells of the BBB (Varatharaj and Galea, 2017

Vitamin C, for instance, helps to elevate glutathione in red blood cells and lymphocytes, while vitamin E works hand in glove with the antioxidant to prevent damage from reactive oxygen

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It acts as a free radical scavenger, upregulating antioxidant enzymes such as superoxide dismutase and catalase (9)

Many people struggle with low B12 levels due to factors like diet, certain health conditions, or the natural effects of agingoften resulting in symptoms such as fatigue, weakness, or trouble concentrating
