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Combined oral delivery of ebselen and allopurinol reduces multiple cisplatin toxicities in rat breast and ovarian cancer models while enhancing anti-tumor activity

The large, dimeric enzyme operates through a FAD cofactor and two essential cysteines, one of which is proximal to the glutathione disulfide docking site and the other to the FAD cofactor [129]

Because the brain is especially vulnerable to oxidative stress (16), vitamin Cs antioxidant role helps maintain healthy nerve cells and supports overall cognitive function

Without the enzyme, the reaction rate dropped significantly to approximately 1.20 micrometers per minute

M.PautzA.et al (2011)

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