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The body can additionally clear MGO through the kidneys without prior detoxification [22]
The constant levels of marker proteins such as GAPDH, combined with observations indicating that knockdown of the UPR element, BiP/Grp78 , revealed no detectable effects on Nrf2, GCLC, or glutathione, further support the conclusion that NFT-mediated stabilization of Nrf2 is a major contributor to its accumulation and the subsequent stimulation of GCL and glutathione synthesis
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Effects of Protein Kinase C Inhibitor,chelerythrine Chloride,on Drug-Sensitivity of NSCLC Cell Lines
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Biomed Pharmacother 147:112671
