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Activation of serotonin receptor 7 (5-HT 7 R) using its agonist LP-211 showed beneficial effects on anxiety-like behaviors, social and cognitive deficits, in the VPA model [62]

It has been shown that ROS generation through Hcy auto-oxidation in the presence of copper has been implicated in endothelial cell injury and suggests that Hcy influences Ca 2+ homeostasis, which is linked to ischemia-reperfusion injury in hypoxic heart cells during myocardial infarction [18,23]

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The lack of outcome difference may be due to 97% of patients who received GO 2 months before HCT [69]

[DOI] [PubMed] [Google Scholar] 207.Frederickson CJ, Koh JY, and Bush AI

10.1038/s41526-022-00193-9 106
