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Where does the available human evidence sit on the study design hierarchy: case report (low grade), retrospective series, or controlled trial (higher grade)

Therefore, these confounders must be strictly controlled during study so that the results across samples and studies can be comparable

Robaire, B., Hinton, B

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Stimuli-like ionizing radiation, chemotherapeutics, and other drug damage, oxidative stress, and senescence-induced telomere dysfunction can mediate such damage, subsequently leading to the aggregation of aberrant macromolecular substances

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