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Lastly, 3 (16.6%) patients developed hypocarnitinemia at the last timepoint follow-up (2+ years)

Additionally, we measured the body weight and standard length of the 3-month-old F1 fish and observed that the LMNA transgenic fish were longer and heavier than the AB(WT), but no difference compared to LMNA (WT) fish (Fig

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Authors contribution All authors of the study substantially contributed to conception, design, acquisition and analysis of data and interpretation of the study

The protein carnitine-acylcarnitine translocase, also known as solute carrier family 25 member 20 (SLC25A20), is an important component of the inner mitochondrial membrane and is essential for the transport of acylcarnitine into the mitochondrial matrix ( Cytochrome c oxidase subunit 4 (COX4I1) is part of an enzyme complex located in the inner mitochondrial membrane and belongs to the electron transfer chain ( The basal respiration offers insights into the basal status of oxidative phosphorylation (OXPHOS) in PBMC and comprises two components: mitochondrial ATP production and proton leak

This helps ensure that a greater proportion of the weight lost comes from fat, leading to a healthier, leaner body composition