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H 2 O 2 is able to readily react with free iron or copper (i.e., Fenton reaction) to form hydroxyl radicals, which are highly reactive and short-lived species [8,9]

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However, evaluation of affected dogs in the early (subclinical) stage, reveals that copper accumulation precedes cholestasis,27, 95 and decreased biliary excretion of radiolabeled copper has been documented

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