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However, severe or persistent fatigue can be a sign of a health issue

doi: 10.1038/s41418-021-00814-y 86 MusaogullariA.ChaiY

doi: 10.1007/BF02532375

doi: 10.3389/fgene.2012.00007 23 BoffettaP.JourenkovaN.GustavssonP

Collectively these observations suggest that treatments targeting lipid pathways, such as omega-3 supplementation or agents like metformin which have been shown to prevent LC (64), could provide benefit as they have been found to positively impact AA metabolism (65)
