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Concurrently, it disrupts the PI3K/Akt/mTOR cascade, balancing the interplay between apoptosis and protective autophagy, which often culminates in synergistic cell death in resistant cancer models [33, 42]

Statements Author contributions WY: Conceptualization, Visualization, Writing original draft, Writing review & editing

Pathak and Sriram, 2023a)

Early-life nicotine or cotinine exposure produces long-lasting sleep alterations and downregulation of hippocampal corticosteroid receptors in adult mice

[19] has merit, as accumulation of acyl-CoAs can inhibit the activity of some tricarboxylic acid (TCA) cycle enzymes, adenine nucleotide translocation and ATP formation [8991]

It has also been shown that lowering hyperoxia in the retina after rod death, by placing the RP mice in a hypoxic chamber result in decreased oxidative damage on cones, and better cone vision [9]