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Tremors, bradykinesia, and postural instability manifest following a 7080% depletion of dopaminergic neurons in the substantia nigra (SN) [3] and subsequently, dopamine release in the striatum is impaired [4]

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10.1016/S0197-4580(02)00065-9 16 BraidyN.BergJ.ClementJ.KhorshidiF.PoljakA.JayasenaT.et al (2019)

Furthermore, simvastatin can reduce the expression of 1 integrin (44%) and type 1 collagen (60%) compared to untreated leiomyoma cells [84]