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A meta-analysis of randomized controlled trials found statins reduced levels of plasminogen activator inhibitor-1, resulting in increased production of plasmin, a fibrinolytic enzyme
They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding ~300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects
These include the deficiencys severity, underlying medical conditions, and how well the patient responds to treatment
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