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75 FUTURE PERSPECTIVES The STS compound used in the pediatric RCTs has recently been licensed by the FDA (Pedmark) and EMA and MHRA (Pedmarqsi), and is ready for implementation into current practice in children with cancers requiring cisplatin therapy

Interestingly, CBS is upregulated by transcription factors such as nuclear factor erythroid 2-related factor 2 (NRF2) 17 , SP1/3 18 , and NFY 18 and its upregulation confers resistance against ferroptosis in ovarian cancer cells 17
Natural Lightening of Skin Glutathione helps to reduce the production of melanin

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Glutathione S-transferase Mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1
(Lond.) 42 , 618624 (2018)
