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Vitamin B12 is also essential for the health of your skin, hair and nails

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Impairment of remethylation occurs when there is dietary deficiency of folate or vitamin B12, or defects in MTHFR, methionine synthase, or one of the enzymes required for the formation of methylcobalamin (7)

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Other interventions may involve blood pressure support with intravenous fluids and vasopressors, and correction of electrolyte abnormalities or acid-base disorders (commonly an anion gap metabolic acidosis)