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B12/MIC Injections are not available in AR

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They emphasize that the efficacy of cuproptosis induction is not solely determined by copper availability but is profoundly influenced by the cellular context, including metabolic pathways, splicing fidelity, and post-translational modifications

In addition to the lack of functional NNT in C57BL/6J mice (Ronchi et al., 2013), they also lack the stop codon for the NADK2 gene, resulting in a longer, potentially unstable mitochondrial protein (Timmermans and Libert, 2018) that may further contribute to the dysfunctional mitochondrial NADPH generation and antioxidant function

As discussed below in Section Molecular chaperones: Facilitators of protein folding dynamics, molecular chaperones are now recognized not only for their role in protein folding but also for their involvement in protein transport, degradation, and signaling pathways