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An initial foray into the question "Does B12 cause acne?" reveals a complex answer

Vitamin B12 injections require a prescription and are used under provider supervision

Based on six clinical trials involving approximately 900 participants, AOD-9604 has demonstrated an excellent safety profile indistinguishable from placebo

Cureus 17(10): e94838

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But people can get blemishes from flu shots, so there is no direct correlation that B12 causes blemishes. Unfortunately though, theres no way to know beforehand if B12 will cause a breakout