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10.1177/0333102413490347 Cephalalgia 73 YuS.LiuR.ZhaoG.YangX.QiaoX.FengJ.et al (2012)

They represent structural changes in the skin that occurred during the healing process after inflammatory acne

22 This compromises endothelial barrier function and vasoregulation, reducing vasodilatory factors (eg, NO, prostacyclin) while increasing vasoconstrictors (eg, ET-1, TXA2), exacerbating vasoconstriction