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Table 2 Studies of PDE-5 inhibitor treatment for Peyronies disease Full table L-arginine L-arginine is a NO precursor that stimulates NO synthase

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Genetic deletion of the flexible X/Y linker leads to an increase in basal activity, but this activity can be further stimulated by G-proteins, suggesting there is more to G-protein regulation of PLC activity than removal of the X/Y linker steric occlusion of the active site

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