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Leptin is usually transported across the blood-brain barrier by a specialized leptin-transporter that is impaired in obesity [17]

We should like to stress that B12 was selected for these purely epidemiological considerations and with no malice aforethought

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In addition, acetyl-L-Carnitine administration affects protein synthesis, increasing the intracellular amino acid pool useful in speeding up the energy metabolism of Sertoli cells

Collectively, these targets form a multi-target framework addressing SAEs inflammation-oxidation-energy failure core, providing insights for neuroprotection