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Notably, while excess iodine is well known to trigger thyroid autoimmunity in susceptible individuals, evidence from the literature is reassuring that an adequate iodine status (defined as a UIC between 100 g/L and 299 g/L) is safe in this regard [25, 26]

The fact of the matter is, if you have that much histamine and you can scratch on your arm, dermatographia, it's called, then you probably have a lot of oxidative stress going on

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[PubMed] [Google Scholar] [76].Hassamal S, Miotto K, Dale W, Danovitch I, Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures, Am