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Melatonin is a hormone that the body naturally makes in the pineal gland in the brain

On the other hand, ginkgo and some flavonoids may inhibit CYP3A4 or Pg-pg, leading to increased drug exposure and an increased risk of toxicity, such as myelosuppression, neuropathy, or hepatotoxicity (203)

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In some cases, it can go higher than 100, and some people even score over 300
