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In vitro COMT inhibition assays demonstrated that the tolcapone-loaded PLGA nanoparticles achieved comparable enzyme inhibition efficacy to free tolcapone, confirming therapeutic retention which was achieved in addition to a controlled-release profile and reduced cytotoxicity

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They disappeared because the machinery moved slowly and patients couldn't wait

After culturing for 30 h, cells were stained with 5 g ml 1 calcein-AM at 37 C for 15 min

In conjunction with its cofactor NADPH, TXNRD (also termed TrxR) catalyzes the disulfide reduction of TXN [50]

Subcutaneous injections are usually given at a 45- to 90-degree angle