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L-arginine is also converted into a substance called nitric oxide (NO)

Acta 192 , 462467 (1969)

Furthermore, when apoptosis and necroptosis fail to occur, caspase-8 can be involved in the activation of caspase-1 and inflammasome to trigger pyroptosis, a strongly proinflammatory cell death modality associated with the release of IL-1 and IL-18 [145, 146]

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Shetty V, Nickens Z, Testa J, Hafner J, Sinnathamby G, Philip R

Bergsbaken T, Fink SL, Cookson BT (2009) Pyroptosis: host cell death and inflammation