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A previous study has shown that the combination of GLP-1R agonist and angiotensin receptor blocker (ARB) increases natriuresis compared to GLP-1R agonist alone in Otsuka LongEvans Tokushima Fatty rats, a model of obese type 2 diabetes [68]

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Compared to the crystal structure or simulation of PF-06372222, these residues (marked red in e g ) were exposed to solvent by 40100 2 in the simulation of compound 2 ( g , i )