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FDA approves new psoriasis drug Cosentyx
The LD50 value as per the acute oral toxicity study is 7100 mg/kg in mice [276]

J.NisbetD

After 30 years of research on AQP4, we have a solid grasp on the role of this water channel in brain physiology and pathophysiology

They highlight promising candidates for further testing, bridging computational predictions and therapeutic development

A similar type of approach using a control circuit responding to the target end-product for successfully enhancing biosynthesis in yeast remains poorly explored
