dihexa clinical trials human studies First in human trial |

Supplementary material The Supplementary Material for this article can be found online at: References 1 AkmanS.AkkocS.ZeyrekC

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p = 0.003) compared to vehicle controls (10.4 2.13 V)

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Putting the Results in Context The improvement seen in the active group (2650% on the investigator scale) over 6 months is encouraging, but context is essential: The improvement level is broadly comparable to other copper peptide studies, though direct comparison is difficult because this study used a categorical improvement scale rather than exact hair counts

The mechanism is real: GHK-Cu activates Wnt/beta-catenin signaling, reduces androgen receptor sensitivity, and suppresses the perifollicular inflammation that quietly chokes follicles over time