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Indeed, after a decade or so, those who had been taking high-dose B6 supplements had about a 40 percent higher hip fracture risk, but not those taking B12

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10.1021/acs.langmuir.8b03810 Langmuir 10 BaiY.ZhangB.ChenL.LinZ.ZhangX.GeD.et al (2018)

This is indicative of their potential as immune adjuvants capable of modulating cellular immunity, which can be leveraged to overcome the limitations of traditional aluminum-based adjuvants, which predominantly elicit humoral immunity [19]